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Anti-PD-1 antibodies / PD-1 inhibitors + Fecal Microbiota Transplantation (FMT) has shown some preliminary results in the treatment of Gastrointestinal cancers, particularly for patients who have developed resistance to anti-PD-1 therapy. This approach aims to enhance the efficacy of immunotherapy by modulating the gut microbiome.
A single-arm, open-label trial explored the efficacy of FMT combined with nivolumab in patients with anti-PD-1 resistant/refractory Gastrointestinal cancers
Peng et al. 2023 Journal of Clinical Onco…