Fecal Microbiota Transplantation (FMT) & Melanoma (cutaneous)

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Why is the investigation of an Fecal Microbiota Transplantation (FMT) in cutaneous melanoma plausible?

Fecal Microbiota Transplantation (FMT) is emerging as a plausible strategy to (partly) overcome resistance to PD‑1–based immunotherapy in advanced cutaneous melanoma, with several small trials showing meaningful response rates but still limited sample sizes and no regulatory approval
Davar et al., 2021 Science 371: 595-602
Vongsavath et al. 2024 Cancers (Basel) 16(3): 499

How does Fecal Microbiota Transplantation (FMT) work in Melanoma (cutaneous)?

Unfortunately, for the randomized clinical trials NCT04577729 and NCT05251389 as well as for the non-randomized clinical trial NCT03353402 no published results were found as of May 2026

References (Sources)

Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients
Davar et al., 2021 Science 371: 595-602
The Use of Fecal Microbiota Transplant in Overcoming and Modulating Resistance to Anti-PD-1 Therapy in Patients with Skin Cancer
Vongsavath et al. 2024 Cancers (Basel) 16(3): 499
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11/5/2026

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