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Live Akkermansia muciniphila rescues exhausted CD8+ Cytotoxic T Lymphocytes (CTLs) , converting them into cytotoxic subpopulations critical for tumor cell killing
The effect is achieved by disrupting immunosuppressive interactions. These occur in the tumor microenvironment. An example is the Chemokine (C-X-C motif) ligand 3 (CXCL3)-CD274 (Programmed death-ligand 1 (PD-L1)) axis. This axis exists between [cancer-ass…