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Scientists still do not fully understand how the body and microbes change bile acids and related fats (1).
To learn more, researchers searched 1.2 billion public mass spectrometry records and created a reusable library of bile acid signals (1).
The library revealed thousands of bile acid changes in animals, humans, and microbes. The study shows that bile acids have many more forms than previously known (1).
Researchers also found bile acids linked to polyamines. These compounds were common in meat-eating animals and were also found in humans (1).
Polyamine-linked bile acid levels changed when people switched from a Mediterranean diet to a typical American diet (1).
Bile acid metabolites are molecules from the hepatic and microbial conversion of cholesterol. They play essential roles not only in digestion but also as signaling molecules that influence metabolism, immunity, and disease processes (2, 3, 4).
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