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Interleukin-33 (IL-33) causes the migration of Group 2 ILCs (ILC2) cells from the intestine to the pancreas. There, they release lymphotoxin (Ltb). This helps form tertiary lymphoid structures (TLS) in tumors, which are associated with better cancer outcomes. Thus, administering IL-33 to mice increases these immune structures in pancreatic tumors, but only if ILC2 cells are present and …