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Interleukin-33 (IL-33) is a molecule that helps guide the early development of CD8+ Cytotoxic T Lymphocytes (CTLs). However, we don't fully understand how it helps these cells become long-term residents in body tissues.
Transcription factor 7 (T-cell specific, HMG-box) (TCF7) expressing CD8+ Cytotoxic T Lymphocytes (CTLs) can self-renew like stem cells, a key for immune defense against chronic viral infections and cancer. A decisive factor for this property is…