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Bacteria have immune systems to detect and defend against mobile genetic elements, such as phages.
The interaction between Gene transfer agents (GTAs) (i.e., domesticated prophages) and bacterial immune systems is not well understood. A study using transposon mutagenesis and deep sequencing in Caulobacter crescentus identified a system called LypABC, crucial for GTA-mediated cell lysis and gene transfer. It is not needed for DNA packaging into GTA particles but is necessary for host cell lysis. The peptidase domains o…