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Excessive leptin and its signaling activate gastric tumors. This activation occurs by inhibiting cytokine signaling suppressors in gastrointestinal epithelial cells.
The process increases the expression of ectopic molecules such as intestinal mucin 2 and Paneth cell marker PLA2. It decreases the expression of transcription factor SRY-box transcription factor 2 (SOX2) and [Hydrogen potassium ATPase](brain://wxp5lMd7ZkizERko-DObkQ/Hydrogen…