Loading…

Medical Research Finder

meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Phospholipase A2 (PLA2)

Welcome to meRfi Microbiome!

Please register to continue your trial period!

meRfi Microbiome provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.

Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.

Start your free trial and transform your understanding of the gut microbiota today!

Phospholipase A2 (PLA2) breaks down phospholipids by hydrolyzing the sn-2 position of phospholipids to release lysophospholipids and Fatty acids

PLA2 activity

PLA2s are key in lipid mediator biosynthesis. They release Arachidonic acid (AA) from membranes. AA is a precursor for eicosanoids like prostaglandins (PGs) and leukotrienes (LTs).
Murakami et al. 2023 Immuno…

A new era of secreted phospholipase A2
Murakami et al. 2015 J Lipid Res 56(7): 1248-1261
Review
Biochemistry and physiology of mammalian secreted phospholipases A2
Lambeau & Gelb 2008 Annu Rev Biochem 77: 495-520
Review
Modulation of immunity by the secreted phospholipase A 2 family
Murakami et al. 2023 Immunol Rev 317: 42-70
Review
Novel functions of phospholipase A2s: overview
Murakami 2019 Biochim Biophys Acta Mol Cell Biol Lipids 1864(6): 763-765
Phospholipase A 2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention
Dennis et al. 2011 Chem Rev 111(10): 6130-6185
Review
Recent progress in phospholipase A 2 research: from cells to animals to humans
Murakami et al. 2011 Prog Lipid Res 50(2): 152-192
Review

7/1/2026