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Medical Research Finder

meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Angiopoietin-like protein 4 (ANGPTL4)

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The protein is a serum hormone directly involved in regulating lipid metabolism.

Inulin treatment of mice increased the level of ANGPTL4
Guo et al. 2022 J Food Biochem. 46: e14063

Mice lacking ANGPTL4 exhibited enhanced adipose lipoprotein lipase (LPL) activity, lower plasma triacylglycerol levels and improved glucose homeostasis compared with wild type mice
Janssen et al. 2018 Diabetologia 61: 1447-1458

The loss of angiopoietin-like 4 (ANGPTL4) in mice with die…

A randomised, controlled, crossover study of the effect of diet on angiopoietin-like protein 4 (ANGPTL4) through modification of the gut microbiome
Blædel et al. 2016 J Nutr Sci 5: e45
Angiopoietinlike protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice
Xu et al. 2005 Proc Natl Acad Sci USA 102: 6086-6091
Gut microbiota and short chain fatty acids partially mediate the beneficial effects of inulin on metabolic disorders in obese ob/ob mice
Guo et al. 2022 J Food Biochem. 46: e14063
Loss of angiopoietin-like 4 (ANGPTL4) in mice with diet-induced obesity uncouples visceral obesity from glucose intolerance partly via the gut microbiota
Janssen et al. 2018 Diabetologia 61: 1447-1458

7/2/2026