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In a tumor imparing microenvironment the myeloid-derived suppressor cells (MDSC) are decreased, M1 macrophage differentiation is increased, the Th1 differentiation of CD4+ T cells is promoted and CD8 + T cell activated.
In addition, senescent cells from different origins can be added to the list of functionally important cell types in the Tumor Microenvironment (TME)
Microbiota signals program [mononuc…