Myeloid-Derived Suppressor Cells (MDSCs) & Tumor Microenvironment (TME)

Myeloid-Derived Suppressor Cells (MDSCs) play a crucial role in shaping the Tumor Microenvironment (TME) and promoting cancer progression.

Myeloid-Derived Suppressor Cells (MDSCs) interact with cancer cells within the tumor microenvironment (TME) via direct and indirect mechanisms: production of soluble factors and cytokines, expression of surface inhibitory molecules, release of exosomes. The mutual relationship between MDSCs and tumor cells leads to immune escape and cancer growth.
Giannotta et al. 2023 Front Immunol. 13: 1102471

see also:
Immune escape