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In a tumor imparing microenvironment the myeloid-derived suppressor cells (MDSC) are decreased, M1 macrophage differentiation is increased, the Th1 differentiation of CD4+ T cells is promoted and CD8 + T cell activated.
In addition, senescent cells from different origins can be added to the list of functionally important cell types in the Tumor Microenvironment (TME)
Microbiota signals program mononuclear phagocytes in the Tumor Microenvironment (TME) toward immunostimulatory monocytes and dendritic cells (DCs)
Our study uncovers a mechanistic link between the microbiota and the innate Tumor Microenvironment (TME) that can be harnessed to improve cancer therapies
Single-cell RNA sequencing revealed that the absence of microbiota skews the Tumor Microenvironment (TME) toward pro-tumorigenic macrophages
Metabolic features of cancer cells and the tumor microenvironment impose constraints on immune cell metabolism that can favor immunosuppressive phenotypes and block antitumor responses
Microbiota modulation with a high-fiber diet triggered the intratumoral IFN-I-NK cell-DC axis and improved the efficacy of immune checkpoint blockade (ICB)
Metabolites in the Tumor Microenvironment (TME), in turn, also affect the differentiation and effector function of immune cells
PD‑1 suppresses T‑cell activity, mostly within the peripheral tissues & in the Tumor Microenvironment (TME)
In tumor microenvironments, T cells are metabolically compromised due to severe nutrient deficiencies, particularly glucose and amino acids
This leads to the inactivation of mTOR and other kinases controlling T cell effector functions and their proliferation
see also:
Cancer immunology / Tumor immunity & Metabolic regulation / Metabolism
Cellular metabolism & Immune Response