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Medical Research Finder

meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Laccase domain-containing 1 protein (LACC1)

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Aliases: C13orf31, FAMIN

LACC1 is an endogenous isocyanic acid synthase, converting L-citrulline to L-Ornithine and isocyanic acid (HNCO)
Wei et al. 2022 Nature 609: 348

LACC1 inhibits pro-inflammatory cytokine signaling and protects from S. Typhimurium infection
Wei et al. 2022 Nature 609: 348

LACC1 bridges arginine metabolism with polyamine synthesis in [inflammatory…

LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages
Wei et al. 2022 Nature 609: 348
LACC1 regulates TNF and IL-17 in mouse models of arthritis and inflammation
Skon-Hegg et al. 2019 J Immunol. 202: 183-193
Myeloid cell expression of LACC1 is required for bacterial clearance and control of intestinal inflammation
Kang et al. 2020b Gastroenterology 159: 1051-1067
Pathogen recognition and inflammatory signaling in innate immune defenses
Mogensen 2009 Clin. Microbiol. Rev. 22: 240-273
Review
The Immunological Genome Project: networks of gene expression in immune cells
Heng et al. 2008 Nat. Immunol. 9:1091-1094

7/1/2026