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Polyamine synthesis represents one of the most profound metabolic changes during T cell activation, but the biological implications of this are scarcely known.
Deficiency in ornithine decarboxylase, a crucial enzyme for polyamine synthesis, results in a severe failure of T helper cells to adopt correct subset specification, underscored by ectopic expression of multiple cytokines and lineage-defining transcription factors across TH cell subsets.
Mammalian synthesis of polyamines is shown: [Arginase-1 (AR…