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Genetically stratified therapy for Mesothelioma is unavailable
Fennell et al. 2022 The Lancet Oncology 23: 374-381
It is essential to correctly identify the malignant pleural mesothelioma (MPM) histology to determine an optimal treatment plan.
Patients with nonepithelioid malignant Pleural mesothelioma may have a greater magnitude of benefit to dual immunotherapy checkpoint inhibitors and this regimen should be preferred in the frontline setting for these patients.
However, all patients with malignant Pleural mesothelioma can derive benefit from immunotherapy treatments, and these agents should ultimately be used at some poi…