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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Aryl Hydrocarbon Receptor (AhR) & Pancreatic Ductal Adenocarcinoma (PDAC) / Pancreatic Cancer

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In patients with PDAC, high Aryl Hydrocarbon Receptor (AhR) expression is associated with rapid disease progression and mortality, as well as with an immune-suppressive TAM phenotype, suggesting conservation of this regulatory axis in human disease.
Hezaveh et al. 2022 Immunity 55: 324-340.e8

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Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity
Hezaveh et al. 2022 Immunity 55: 324-340.e8

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7/1/2026

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Aryl Hydrocarbon Receptor (AhR) & Pancreatic Ductal Adenocarcinoma (PDAC) / Pancreatic Cancer

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