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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Cancer / Tumors & Tryptophan metabolites

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Tryptophan metabolites affect cancer in many ways. They influence development and therapy outcomes. Effects range from chemoprevention to immunotherapy
Hezaveh et al. 2022 Immunity 55: 324-340.e8
Fong et al. 2023 Gut 72: 2272-2285
Tintelnot et al. 2023 Nature 615: 168–174
Zhang et al. 2023b Cell Metab 35: 943-960
Jia et al. 2024 Cell 187: 1651-1665

Reports on their mechanisms and effectiveness vary. This is due to several factors:

Diversity of cancer types, like colorectal and pancreatic.

Different therapeutic strategies, such as chemotherapy, radiotherapy, immunotherapy, or cancer vaccines.

Intestinal or intratumor bacterial Tryptophan metabolites.

Complex Trp catabolism by one bacterial strain or multiple species.

Differences in research me…

References (Sources)

Emerging chemophysiological diversity of gut microbiota metabolites
Lin et al. 2024 Trends in Pharmacological Sciences 45(9): 824
Review
Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition
Cui et al. 2024 Nat Cell Biol 26: 124-137
Lactobacillus gallinarum-derived metabolites boost anti-PD1 efﬁcacy in colorectal cancer by inhibiting regulatory T cells through modulating IDO1/Kyn/AHR axis
Fong et al. 2023 Gut 72: 2272-2285
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8(+) T cell immunity
Zhang et al. 2023b Cell Metab 35: 943-960
Microbial metabolite enhances immunotherapy efﬁcacy by modulating T cell stemness in pan-cancer
Jia et al. 2024 Cell 187: 1651-1665
Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer
Tintelnot et al. 2023 Nature 615: 168–174
Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity
Hezaveh et al. 2022 Immunity 55: 324-340.e8

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7/1/2026

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