Imidazole propionate / Imidazol-4-one-5-propionic acid

Imidazole propionate, also known as imidazol-4-one-5-propionic acid, is a metabolite produced by the gut microbiota from the amino acid histidine. Its production and levels in the body are influenced by the composition of the gut microbiota and dietary habits, particularly the intake of red meat and histidine-rich foods
Zhu et al. 2022c Curr Dev Nutr. 6(Suppl 1): 1041

Imidazole propionate has been identified as a marker for type 2 diabetes mellitus (T2DM). It is associated with impaired glucose metabolism and can reduce the efficacy of metformin, a common diabetes…