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Metformin is a primary medication for Type 2 Diabetes (T2D). Its exact mechanism of action is not fully understood. Initially, the liver was considered the main target of metformin. Recent findings indicate that the gut also plays a significant role in reducing glucose levels through new mechanisms. Knowledge of metformin's impact on both the gut and liver is essential for improving patient care and developing new treatments for T2D.
Barroso et al. 2023 Trends in Pharmacological Sciences 44(7): 45…