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Clostridium sordelli ATCC 9714 is a secondary bile acid producing bacterium
A new extracellular metalloproteinase called Mcs1 (Metalloproteinase of Clostridium sordellii 1) was identified in Clostridium sordelli ATCC 9714
Mcs1 can cleave human Vascular cell adhesion molecule (VCAM)-1 in vitro.
Mcs1 may play a role in the pathogenesis of C. sordellii infections and may contribute to the severe capillary leak and leukemoid reactions observed in patients.
Aldape et …