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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

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Mcs1 (Metalloproteinase of Clostridium sordellii 1)

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Discovery and Identification

Mcs1 (Metalloproteinase of Clostridium sordellii 1) is a newly discovered extracellular metalloproteinase produced by the lethal pathogen Clostridium sordellii, which affects both animals and humans. The open reading frame encoding Mcs1 was identified within the ATCC 9714 genome of C. sordellii.

Function and Activity

VCAM-1 Cleavage

Mcs1 has been shown to cleave human Vascular cell adhesion molecule (VCAM)-1 in vitro. VCAM-1 is critical for:

Hematopoietic precursor retention

Leukocyte diapedesis

Proteolytic Activity

The proteolytic activity of Mcs1 is controlled by:

Electr…

References (Sources)

Experimental identification and computational characterization of a novel extracellular metalloproteinase produced by Clostridium sordellii
Aldape et al. 2017 RSC Adv. 7(23): 13928-13938

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7/1/2026

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