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Tumor-associated carbohydrate antigens (TACA) result from the aberrant glycosylation that is seen with transformation to a tumor cell.
The carbohydrate antigens that have been found to be tumor-associated include the mucin related MUCIN-1 (MUC1) / CA15-3 - Tn (GalNAc-Ser/Thr), Sialyl Tn, and Thomsen-Friedenreich antigens, the blood group Lewis related Lewis(Y), Sialyl Lewis(X) and Sialyl Lewis(A), and Lewis(X) (also know…