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B-vitamin cross-feeding remains an important area of research because, although microorganisms need only small amounts of these vitamins for metabolism, many cannot produce them independently and must obtain them from other organisms (8). Humans cannot synthesize B vitamins de novo, which means they must obtain them through their diet or from microbial synthesis in the gut (3).
B vitamins represent a vital group of micronutrients, serving as indispensable cofactors for numerous enzymes or directly participating in host metabolism (1). They are essential nutrients that play a critical role in many physiological processes important for human health. They serve as precursors for coenzymes involved in various metabolic pathways, and deficiencies in these vitamins can lead to a range of health issues, including cognitive dysfunction, neuropathy, cardiovascular disease, and osteoporosis (2, 3).
Bacterial metabolism pathways are involved in B vitamin biosynthesis. The B-vitamin biosynthesis and “sharing” among the gut microbiota may be a potential stabilizer of the gut microbiome (4, 5).
Most B vitamins, when insufficient, can contribute to Cardiac dysfunction and related metabolic issues due to their vital roles in energy production and metabolic pathways (6, 7).
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see also:
B vitamins & Gut microbiota
Gut microbiota & Vitamins