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Macrophages acquire iron via TFR-mediated endocytosis of holo-TF or recycling of senescent erythrocytes. Heme oxygenase catalyze the degradation of heme to iron, Carbon monoxide (CO), and biliverdin, after which iron is transported to the cytoplasm by DMT1. Cytoplasmic iron can be used for cellular processes, stored in ferritin, or transported out of the macrophage by [FPN](brain://RWEBHPGDk0SYJnp2NSM2yQ/FerroportinF…