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Erythroid precursors acquire iron via transferrin receptor (TFR)-mediated endocytosis of holo-TF; iron is then transported into the cytoplasm by DMT1. Cytoplasmic iron can subsequently be shuttled to mitochondria for use in heme biosynthesis.
Hemoglobin or heme released upon erythrocyte lysis is avidly scavenged by Haptoglobin (Hp) or Hemopexin (Hpx), respectively.
Cassa…