Probiotics (living agents) & Preclinical/Clinical Data

Probiotics, despite being a significant factor in healthcare spending, often lack robust evidence to support their use. Consequently, their actual impact on human health remains a topic of ongoing debate.
Collinson et al. 2020 Cochrane Database Syst Rev 12: CD003048

Selecting an appropriate probiotic is challenging because various factors come into play: the strain- and disease-specific efficacy of probiotic products, differences in the mechanisms of action of different probiotic strains, differences in manufacturing processes and quality control of the products, and differences in international regulatory requirements. International guidelines from infectious disease or pediatric disease organizations do not always agree on which probiotics should be used for which type of disease.
Sniffen et al. 2018 PLoS…