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Escherichia coli bacteria that make the molecule colibactin are termed pks + E. coli)
The Colibactin self-resistance protein (ClbS) can be expressed on engineered bacteria surfaces. This shields hosts from genotoxic effects. We fuse ClbS with outer membrane protein A (ClbS–OmpA) in Escherichia coli. ClbS–OmpA on the surface reduces DNA damage. It also prevents cell cycle arrest in human cells and organoids. This method is better than D-serine. D-serine is a small-molecule inhibitor of colibactin synthesis. Engineered bacteria helped …