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Colibactin self-resistance protein ClbS is a bacterial antitoxin enzyme that protects colibactin-producing strains (notably pks+ Escherichia coli) from their own genotoxic metabolite by detoxifying its reactive warhead and binding DNA
Colibactin self-resistance protein (ClbS) is encoded within the pks/colibactin biosynthetic island and is essential for viability of colibactin-producing E. coli, because it neutralizes colibactin before it can damage the p…