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The dysregulation of bile acids synthesis and transport in the liver leads to the release of various inflammatory cytokines and the severe accumulation of bile acids, which promotes liver cancer.
Disturbance of bile acids on cell membranes can also activate intracellular PLA2, allowing cell membranes to release arachidonic acid, which is metabolized by lipoxygenase and [COX](brain://hlT_kFrN0kqLPE3P84qGN…