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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Bacterial Polysaccharide A (PSA) & Dendritic Cells (DCs)

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We hypothesized that this direct Bacterial Polysaccharide A (PSA) –T cell interaction might not suffice for immunoprotection; and that APCs may be necessary.
Dasgupta et al. 2014 Cell Host and Microbe. 15: 413-423

Bacterial Polysaccharide A (PSA) stimulates Toll-like receptor 2 (TLR-2) signaling and IL-12 production by DCs within the Mesenteric Lymph Nodes (MLNs) / Superior mesenteric lymph nodes

References (Sources)

A microbial symbiosis factor prevents intestinal inflammatory disease
Mazmanian et al. 2008
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian et al. 2005
Exploring the Gut-Brain Axis for the Control of CNS Inflammatory Demyelination: Immunomodulation by Bacteroides fragilis’Polysaccharide A
Erturk-Hasdemir et al. 2021
Review
Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms
Dasgupta et al. 2014 Cell Host and Microbe. 15: 413-423
Polysaccharide A from the Capsule of Bacteroides fragilis Induces Clonal CD4+ T Cell Expansion
Johnson et al. 2015a Journal of Biological Chemistry 290: 5007-5014
The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
Round et al. 2011

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Bacterial Polysaccharide A (PSA) & Dendritic Cells (DCs)

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