APCs (antigen presenting cells)

APCs are DCs, B cells, macrophages

How do antigen-presenting cells regulate T-cell functions and immune responses?

Antigen-presenting cells (APCs) are essential because they activate and direct T cells. APCs can promote T cells with either:

• Regulatory functions, which help maintain tolerance and immune homeostasis.


• Effector functions, which drive immune responses.

Kedmi & Littman 2024 Immunity 57(10): 2269-2279

How can dysfunctional antigen-presenting cells cause intestinal inflammation and microbiota dysbiosis?

Dysfunctional APCs can disturb the balance between regulatory and effector T cells. This imbalance may…