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BRAF Protooncogene (V600E) 586-614 (E D L T V K I G D F G L A T E K S R W S G)
BRAF V600E expression in melanocytes
Dhomen et al., 2009
A valine at position 600 in the RAF protein is replaced by a glutamate, aspartate, or a lysine residue (B-RAF V600E, B-RAF V600D, B-RAF V600K). The B-RAF (serine/threonine-protein kinase B-Raf)(MUT) is permanently active in the cytoplasm and activates the MEK / ERK signaling pathway. This helps the corresponding cells to grow independently of [growth…