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In the context of Adoptive T Cell Therapy / CAR-T, Carbonic anhydrase 9 (CAIX) has been targeted in the treatment of Clear Cell Renal Cell Carcinoma (CCRCC).
However, one of the challenges is the potential off-tumor toxicity due to the expression of CAIX on normal tissues, such as the bile duct.
Research has been conducted to develop "fine-tuned" CAIX-targeted CAR T cells with superior efficacy and reduced off-tumor side effects
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