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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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6-Formylindolo(3,2-b)carbazole (FICZ)

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6-Formylindolo(3,2-b)carbazole (FICZ), a tryptophan photoproduct has been proposed to be a physiological agonist for Ahr
Nguyen & Bradfield 2008 Chem Res Toxicol. 21: 102-116

One of the most extensively studied endogenous Aryl Hydrocarbon Receptor (AhR) ligands, 6-Formylindolo(3,2-b)carbazole (FICZ), is a tryptophan-derived AhR ligand that has been shown to bind to the AhR with the highest afﬁnity
[Rannug et al. 1987 J Biol Chem 262(32): 15422-740](brain://nHCNZszSOU6kvsKDskxuxA/RannugEtAl1987JBiolChem2…

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Certain Photooxidized Derivatives of Tryptophan Bind With Very High Afﬁnity to the Ah Receptor and are Likely to be Endogenous Signal Substances
Rannug et al. 1987 J Biol Chem 262(32): 15422-740
The search for endogenous activators of the aryl hydrocarbon receptor
Nguyen & Bradfield 2008 Chem Res Toxicol. 21: 102-116
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6-Formylindolo(3,2-b)carbazole (FICZ)

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