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Upregulation of MGAT5 has also been shown to directly influence cytokine signaling and tumor progression
Furthermore the deficiency of the mgat5 gene, that encodes for a Golgi branching enzyme N-acetylglucosaminyltransferase V (GnT-V) was shown to markedly increases TCR clustering and signaling at the immune synapse, resulting in a lower T cell activation threshold and increased incidence of autoimmune disease in vivo and in human
Demetriou…