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Postbiotics have been found to sensitize cancer cells to immune checkpoint inhibitors (ICIs), potentially enhancing the efficacy of ICI therapy.
Research has revealed that postbiotics can improve ICI-related effects in patients with non-small-cell lung cancer (NSCLC) and other solid tumors.
Bacterial metabolites, particularly phytosphingosine, have the ability to enhance the expression of HLA class I on cancer cells. This enhancement makes the cancer cells more susceptible to lysis by [TA-specific CTLs](brain:/…