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In mammals, DNA is recognized in the context of infection as well as in non-infectious situations of cellular stress and injury via the cGAS-STING pathway, activating the innate immune system.
Because double-stranded DNA (dsDNA) can activate Cyclic GMP-AMP synthase (cGAS), the question arises as to how activation by self-DNA is prevented under homeostatic conditions
see also:
cGAS like receptors (cGLRs)…