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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Haptoglobin-2

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Contents

Haptoglobin is the general term for the protein that binds free hemoglobin. Haptoglobin-2 (often referred to as Hp 2-2) is the protein product of individuals who have two copies of the HP2 allele. This variant has structural and functional differences compared to the Hp 1-1 (homozygous HP1) and Hp 2-1 (heterozygous HP1/HP2) forms, such as forming larger polymeric structures and having lower antioxidant capacity
Sadrzadeh & Bozorgmehr 2004 Am J Clin Pathol 121(Suppl): S97-S104
Vormittag et al. 2005 Haematologica 90(11): 1557-61
Wobeto et al. 2008 Genetics and Molecular Biology 31(3): 602-620
Goldenstein et al. 2012 Pharmacol Res 66(1): 1-6
Lipiski et al. 2013 Antioxid Redox Signal 19(14): 1619-33
Pe…

References (Sources)

Haptoglobin 2-2 genotype is associated with presence and progression of MRI depicted atherosclerotic intraplaque hemorrhage
Marvasti et al. 2017 Int J Cardiol Heart Vasc 18: 96-100
Haptoglobin 2-2 Genotype is Not Associated With Cardiovascular Risk in Subjects With Elevated Glycohemoglobin - Results From the Bruneck Study
Pechlaner et al. 2014 J Am Heart Assoc 3: e000732
Haptoglobin genotype and its role in determining heme-iron mediated vascular disease
Goldenstein et al. 2012 Pharmacol Res 66(1): 1-6
Review
Haptoglobin phenotype 2-2 as a potentially new risk factor for spontaneous venous thromboembolism
Vormittag et al. 2005 Haematologica 90(11): 1557-61
Haptoglobin phenotypes in health and disorders
Sadrzadeh & Bozorgmehr 2004 Am J Clin Pathol 121(Suppl): S97-S104
Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity
Lipiski et al. 2013 Antioxid Redox Signal 19(14): 1619-33
The haptoglobin 2-2 genotype is associated with inflammation and carotid artery intima-media thickness
Dalan et al. 2016 Diab Vasc Dis Res 13(5): 373-6

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