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APCs are responsible for sensing the luminal antigens. Then, they are responsible for presenting the antigens to the T cells in the Peyer’s patches and mesenteric lymph nodes
The tissue microenvironment is pivotal in the differentiation and activation of intestinal macrophages.
Intestinal mucosal macrophages play a crucial role in the body's antimicrobial defenses within the gut. They need to be continuously replenished by circulating monocytes that originate from the bone marrow.
In eubiosis , intestinal macrophages are more effective at clearing bacteria but have reduced cytokine secretion relative to peripheral macrophages
see also:
Biological effects / Functions & Macrophages (CD68s)
Lamina propria