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The precise cause of Diarrhea-predominant Irritable Bowel Syndrome (IBS) (IBS-D) remains unclear. However, it is believed that an abnormal microbiota in the gastrointestinal tract plays a significant role, similar to its involvement in other gastrointestinal conditions like inflammatory bowel disease, antibiotic-associated diarrhea, and colorectal cancer, as well as in [systemic diseases](br…