Enterochromaffin Cells (EC) act as chemosensors within the {intestinal epithelium}. They translate environmental stimuli into the production of serotonin (5-HT) (1).

Interleukin-33 (IL-33) Drives Serotonin Release and Gut Motility

Enterochromaffin Cells (EC) recognize Interleukin-33 (IL-33) and release serotonin (5-HT). IL-33-mediated serotonin release activates [ent…

5-Hydroxytryptamine (serotonin) in the gastrointestinal tract
Gershon 2013 Curr. Opin. Endocrinol. Diabetes, Obes 20: 14-21
Review
A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release
Alcaino et al. 2018 Proc Natl Acad Sci 115(32): E7632
Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways
Bellono et al. 2017 Cell 170(1): 185-198
Interleukin-33 Promotes Serotonin Release from Enterochromaﬃn Cells for Intestinal Homeostasis
Chen et al. 2021 Immunity 54: 151-163
Serotonin Signaling in the Gastrointestinal Tract: Functions, dysfunctions, and therapeutic targets
Mawe & Hoffman 2013 Nat Rev Gastroenterol Hepatol 10(8): 473-486
Review
The chemical coding of 5-hydroxytryptamine containing enteroendocrine cells in the mouse gastrointestinal tract
Reynaud et al. 2016 Cell Tissue Res 364: 489-497
The Serotonin Neurotransmitter Modulates Virulence of Enteric Pathogens
Kumar et al. 2020c

10/23/2026

Enterochromaffin Cells (EC) & Serotonin (5-HT)