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Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

Enterochromaffin Cells (EC) & Serotonin (5-HT)

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Enterochromaffin Cells (EC) cells act as chemosensors on the intestinal epithelium. They translate environmental stimuli into the production of serotonin (5-HT)
Chen et al. 2021 Immunity 54: 151-163

Enterochromaffin Cells (EC) recognize Interleukin-33 (IL-33) and release Serotonin (5-HT). Interleukin-33 (IL-33)-mediated release of Serotonin (5-HT) activates enteric neurons and subsequently promotes intestinal motility. For example, the immediate peristaltic movement facilitates the expulsion of [Trichuris muris…

References (Sources)

5-Hydroxytryptamine (serotonin) in the gastrointestinal tract
Gershon 2013 Curr. Opin. Endocrinol. Diabetes, Obes 20: 14-21
Review
A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release
Alcaino et al. 2018 Proc Natl Acad Sci 115(32): E7632
Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways
Bellono et al. 2017 Cell 170(1): 185-198
Interleukin-33 Promotes Serotonin Release from Enterochromaﬃn Cells for Intestinal Homeostasis
Chen et al. 2021 Immunity 54: 151-163
Serotonin Signaling in the Gastrointestinal Tract: Functions, dysfunctions, and therapeutic targets
Mawe & Hoffman 2013 Nat Rev Gastroenterol Hepatol 10(8): 473-486
Review
The chemical coding of 5-hydroxytryptamine containing enteroendocrine cells in the mouse gastrointestinal tract
Reynaud et al. 2016 Cell Tissue Res 364: 489-497
The Serotonin Neurotransmitter Modulates Virulence of Enteric Pathogens
Kumar et al. 2020c

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