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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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GSDMD-N Domain & Mode of Action (MoA)

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Gasdermin D (GSDMD) undergoes proteolytic cleavage by Initiator Caspases, releasing the GSDMD-N Domain to form membrane pores and the GSDMD-C Domain.
Devant & Kagan 2023 Nat Immunol 24: 1064-1075

GSDMD-N Domain can bind membrane lipids such as phosphatidylserine and cardiolipin, contributing to their ability to disrupt cellular membranes and induce pyroptosis.
Kuang et al. 2017 Proc Natl Acad Sci USA 114(40): 10642-10647

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Molecular mechanisms of gasdermin D pore-forming activity
Devant & Kagan 2023 Nat Immunol 24: 1064-1075
Review
Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis
Kuang et al. 2017 Proc Natl Acad Sci USA 114(40): 10642-10647

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