Pyroptosis

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What Is Pyroptosis, and How Does It Differ from Apoptosis?

Pyroptosis is a highly inflammatory form of programmed cell death mediated by gasdermin (GSDM) family proteins leading to membrane pore formation, cell swelling, and release of pro-inflammatory intracellular contents. Unlike pyroptosis, apoptosis generally preserves membrane integrity and does not trigger a strong inflammatory response.
Patton et al. 2026 Trends Immunol 47: 284-296

Pyroptosis in Host Defense

Pyroptosis plays a pivotal role in host defense against infectio…

References (Sources)

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Shi et al. 2015 Nature 526: 660-665
Get with the program: regulation of T cell death.
Patton et al. 2026 Trends Immunol 47: 284-296
Review
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
Sborgi et al 2016 EMBO J 35: 1766-1778
Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis
Erkes et al. 2020 Cancer Discovery 10: 254
Pyroptosis: gasdermin-mediated programmed necrotic cell death
Shi et al. 2017 Trends Biochem. Sci. 42: 245-254
Pyroptosis: mechanisms and diseases
Yu et al. 2021e Sig Transduct Target Ther 6: 128
Review
Role of pyroptosis in inflammation and cancer
Wei et al. 2022a Cell Mol Immunol 19: 971-992
Review

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10/17/2026

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