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Over the years, neuroinflammation has been posited as a common link between multiple neurological, neurodegenerative, and neuropsychiatric disorders. Processes that precipitate neuroinflammatory conditions, including genetics, infections, physical injury, and psychosocial factors, like stress and trauma, closely link dysregulation in the kynurenine pathway (KP) of tryptophan metabolism possible pathophysiological factor that ‘fuel the fire’ in CNS diseases.
KP of Tryptophan metabolism is ubiquitous in eukaryotic cells and regulates among other [gut-microbiota functions](brain://AGHjti33dEORG5AC1sJkMQ…