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Medical Research Finder

meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Kynurenine pathway

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Kynurenine pathway is the predominant pathway for Tryptophan metabolism, producing various neuroactive metabolites such as kynurenine (KYN), kynurenic acid (KYNA), and quinolinic acid (QUIN).
Wang et al. 2026 Front Microbiol 17: 1820111

Tryptophan metabolites from the Kynurenine Pathway by the gut microbiota suppress inﬂammatory responses in the macrophages.
Su et al. 2022 Cells 11: 2296

IDO expression by dendritic cells: tolerance and tryptophan catabolism
Mellor & Munn 2004
Review
Kynurenine pathway metabolism and the microbiota-gut-brain axis
Kennedy et al. 2017 Neuropharmacology 112: 399-412
Review
Kynurenine pathway modulation by exercise in multiple sclerosis: implications for neuroprotection and inflammation
Hoseini & Ghafari 2025 Cell Mol Neurobiol 45: 74
Review
Polyamines and Kynurenines at the Intersection of Immune Modulation
Proietti et al. 2020 Trends in immunology 41: 1037
Review
The influence of kynurenine metabolites on neurodegenerative pathologies
Pathak et al. 2024 Int J Mol Sci 25: 853
Review
The Microbiota-Tryptophan-Brain Axis in Neurodegenerative Diseases: Pathogenic Mechanisms, Disease-Specific Roles, and Translational Therapeutics
Wang et al. 2026 Front Microbiol 17: 1820111
Review
Tryptophan and indole metabolism in immune regulation
Fiore & Murray 2021 Current Opinion Immunology 70: 7-14
Review

7/1/2026