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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Farnesoid X receptor (FXR / NR1H4) & Localisation / Occurence

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Farnesoid X receptor (FXR / NR1H4) is expressed both in the small intestine (ileum >> jejunum > duodenum) and in the colon
Schubert et al. 2017 Immunological Reviews 279: 23-35

The expression levels of Farnesoid X receptor (FXR / NR1H4) are high in the liver (hepatocytes), intestine ([intestinal epithelial cells (IECs)](brain://29P71l_ANkueEeddeY-YZg/EnterocytesIntestinalE…

References (Sources)

Bile acids: natural ligands for an orphan nuclear receptor
Parks et al. 1999 Science 284: 1365-1368
Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
Wang et al. 1999b Mol. Cell 3: 543-553
Identiﬁcation of a nuclear receptor for bile acids
Makishima et al. 1999 Science 284: 1362-1365
Interactions between bile salts, gut microbiota, and hepatic innate immunity
Schubert et al. 2017 Immunological Reviews 279: 23-35
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Farnesoid X receptor (FXR / NR1H4) & Localisation / Occurence

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