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mesh1 gene is a gene found in metazoan organisms, including humans, that encodes the protein Metazoan SpoT Homolog 1 (MESH1) homologous to the bacterial SpoT hydrolase. MESH1 is a cytosolic NADPH phosphatase. It plays a role in regulating ferroptosis. In bacteria, Bifunctional (p)ppGpp synthase/hydrolase SpoT (SpoT) is a central component of the stringent response, a conserved stress adaptation pathway triggered by environmental and nutritional stresses. The bacterial stringent response is regulated by the alarmone p-ppGpp, whose levels are controlled by synthesis ([RelA](brain://7M0yr3_d51uXABY4ELGIVA/R…