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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)

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CD4+ CD25++ FOXP3 low nTreg / tTreg

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Contents

Origin: Thymus

Markers: CD4 +, CD25 high, CD62L +, CTLA-4 -, FOXP3 low, CD45RA +, CD45RO -, HLA-DR -, CD95 -

The thymus-derived CD4+ CD25 high FOXP3 low nTreg / tTreg are thought to be ‘natural’ Treg cells

Neuropilin-1 and Helios are thought to be more commonly expressed on tTregs, and are often used as distinguishing markers between CD4+ CD25+ FOXP3 high Treg (peripherally induced) (pTreg) and CD4+ CD25++ FOXP3 low nTreg / tTreg
Yadav et al. 2012 J Exp Med 209(10): 1713-1722
Thornton et al. 2010 J Immunol 184(7): 3433-3441

Originate in the thymus and emigrate as naiv…

References (Sources)

CD25+CD127 +Foxp3- Cells Represent a Major Subpopulation of CD8+ T Cells in the Eye Chambers of Normal Mice
Maslanka et al. 2017 PloS One 12(1): e0170021
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
Tai et al. 2005
Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
Thornton et al. 2010 J Immunol 184(7): 3433-3441
FOXP3 + regulatory T cells in the human immune system
Sakaguchi et al. 2010 Nature 10: 490
Review
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
Weiss et al. 2012 J Exp Med 209(10): 1723-1742
Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
Yadav et al. 2012 J Exp Med 209(10): 1713-1722
Regulatory T cells: mechanisms of differentiation and function
Josefowicz et al. 2012 Annu Rev Immunol 30: 531-564
Review

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